Full Citation
Title: Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study
Citation Type: Book, Whole
Publication Year: 2013
ISBN: 0002-9262
ISSN: 18777821
DOI: 10.1016/j.canep.2012.12.005
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PMCID:
PMID: 23312454
Abstract: Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring. © 2012 Elsevier Ltd.
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Authors: Musselman, Jessica R B; Georgieff, Michael; Ross, Julie A.; Tomlinson, Gail E.; Feusner, James H.; Krailo, Mark D.; Spector, Logan G.
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Pages: 318-320
Volume: 37
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