MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Human milk exosomal microrna: Associations with maternal overweight/obesity and infant body composition at 1 month of life

Citation Type: Journal Article

Publication Year: 2021

ISSN: 20726643

DOI: 10.3390/nu13041091

PMID: 33801634

Abstract: Among all the body fluids, breast milk is one of the richest sources of microRNAs (miRNAs). MiRNAs packaged within the milk exosomes are bioavailable to breastfeeding infants. The role of miRNAs in determining infant growth and the impact of maternal overweight/obesity on human milk (HM) miRNAs is poorly understood. The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. Milk samples were collected from a cohort of 60 mothers (30 normal-weight [NW] and 30 overweight [OW]/obese [OB]) at 1-month and a subset of 48 of these at 3 months of lactation. Relative abundance of miRNA was determined using real-time PCR. The associations between the miRNAs of interest and infant weight and body composition at one, three, and six months were examined after adjusting for infant gestational age, birth weight, and sex. The abundance of miR-148a and miR-30b was lower by 30% and 42%, respectively, in the OW/OB group than in the NW group at 1 month. miR-148a was negatively associated with infant weight, fat mass, and fat free mass, while miR-30b was positively associated with infant weight, percent body fat, and fat mass at 1 month. Maternal obesity is negatively associated with the content of select miRNAs in human milk. An association of specific miRNAs with infant body composition was observed during the first month of life, suggesting a potential role in the infant’s adaptation to enteral nutrition.

Url: https://pubmed.ncbi.nlm.nih.gov/33801634/

User Submitted?: No

Authors: Shah, Kruti B.; Chernausek, Steven D.; Garman, Lori D.; Pezant, Nathan P.; Plows, Jasmine F.; Kharoud, Harmeet K.; Demerath, Ellen W.; Fields, David A.

Periodical (Full): Nutrients

Issue: 4

Volume: 13

Pages:

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop