MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Limbic structures and networks in children and adolescents with schizophrenia.

Citation Type: Journal Article

Publication Year: 2008

ISSN: 0586-7614

DOI: 10.1093/schbul/sbm110

PMID: 17942479

Abstract: Studies of adults with schizophrenia provide converging evidence for abnormalities in the limbic system. Limbic structures that show consistent patient/control differences in both postmortem and neuroimaging studies include the anterior cingulate and hippocampus, although differences in the amygdala, parahippocampal gyrus, and fornix have also been observed. Studies of white matter in children and adolescents with schizophrenia tend to show findings that are more focal than those seen in adults. Interestingly, these focal abnormalities in early-onset schizophrenia tend to be more localized to limbic regions. While it is unclear if these early limbic abnormalities are primary in the etiology of schizophrenia, there is evidence that supports a developmental progression with early limbic abnormalities evolving over time to match the neuroimaging profiles seen in adults with schizophrenia. Alternatively, the aberrations in limbic structures may be secondary to a more widespread or global pathological processes occurring with the brain that disrupt neural transmission. The goal of this article is to provide a review of the limbic system and limbic network abnormalities reported in children and adolescents with schizophrenia. These findings are compared with the adult literature and placed within a developmental context. These observations from neuroimaging studies enrich our current understanding of the neurodevelopmental model of schizophrenia and raise further questions about primary vs secondary processes. Additional research within a developmental framework is necessary to determine the putative etiologic roles for limbic and other brain abnormalities in early-onset schizophrenia.

Url: http://www.ncbi.nlm.nih.gov/pubmed/17942479

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2632381

User Submitted?: No

Authors: White, Tonya; Cullen, Kathryn; Rohrer, Lisa Michelle; Karatekin, Canan; Luciana, Monica; Schmidt, Marcus; Hongwanishkul, Donaya; Kumra, Sanjiv; Charles Schulz, S; Lim, Kelvin O

Periodical (Full): Schizophrenia bulletin

Issue: 1

Volume: 34

Pages: 18-29

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop