MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Performance of the pooled cohort equations in cancer survivors: the Atherosclerosis Risk in Communities study

Citation Type: Journal Article

Publication Year: 2023

ISBN: 0123456789

ISSN: 1932-2267

DOI: 10.1007/S11764-023-01379-0

Abstract: Cancer survivors may have elevated atherosclerotic cardiovascular disease (ASCVD) risk. Therefore, we tested how accurately the American College of Cardiology/American Heart Association 2013 pooled cohort equations (PCEs) predict 10-year ASCVD risk in cancer survivors. To estimate the calibration and discrimination of the PCEs in cancer survivors compared to non-cancer participants in the Atherosclerosis Risk in Communities (ARIC) study. We evaluated the PCEs’ performance among 1244 cancer survivors and 3849 cancer-free participants who were free of ASCVD at the start of follow-up. Each cancer survivor was incidence-density matched with up to five controls by age, race, sex, and study center. Follow-up began at the first study visit at least 1 year after the diagnosis date of the cancer survivor and finished at the ASCVD event, death, or end of follow-up. Calibration and discrimination were assessed and compared between cancer survivors and cancer-free participants. Cancer survivors had higher PCE-predicted risk, at 26.1%, compared with 23.1% for cancer-free participants. There were 110 ASCVD events in cancer survivors and 332 ASCVD events in cancer-free participants. The PCEs overestimated ASCVD risk in cancer survivors and cancer-free participants by 45.6% and 47.4%, respectively, with poor discrimination in both groups (C-statistic for cancer survivors = 0.623; for cancer-free participants, C = 0.671). The PCEs overestimated ASCVD risk in all participants. The performance of the PCEs was similar in cancer survivors and cancer-free participants. Our findings suggest that ASCVD risk prediction tools tailored to survivors of adult cancers may not be needed.

Url: https://link.springer.com/article/10.1007/s11764-023-01379-0

User Submitted?: No

Authors: Polter, Elizabeth J; Blaes, Anne; Wolfson, Julian; Lutsey, Pamela L; Florido, Roberta; Corinne, ·; Joshu, E; Guha, Avirup; Platz, Elizabeth A; Prizment, Anna

Periodical (Full): Journal of Cancer Survivorship 2023

Issue:

Volume:

Pages: 1-11

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IPUMS NHGIS NAPP IHIS ATUS Terrapop