MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Associations of endogenous sex hormones with the vasculature in menopausal women: the Study of Women's Health Across the Nation (SWAN).

Citation Type: Journal Article

Publication Year: 2008

ISSN: 1072-3714

DOI: 10.1097/gme.0b013e318154b6f5

PMID: 18209686

Abstract: OBJECTIVE As associations between endogenous sex hormones and the vasculature are not well characterized, the objective was to examine the cross-sectional associations of menopausal status and endogenous sex hormones with vascular characteristics. DESIGN Common carotid artery adventitial diameter and intima-media thickness were determined using B-mode ultrasonography among 483 middle-aged women enrolled in the Pittsburgh and Chicago sites of the Study of Women's Health Across the Nation. RESULTS Sixty-two percent of women were pre- or early perimenopausal (<3 mo amenorrhea), 12% were late perimenopausal (3-12 mo amenorrhea), and 27% were postmenopausal (>or=12 mo amenorrhea). After adjustment for age, compared with pre-/early perimenopause, late perimenopause was associated with a 0.28-mm larger adventitial diameter (P=0.001), whereas postmenopause was associated with a 0.15-mm larger adventitial diameter (P=0.040). Adjustment for traditional cardiovascular risk factors slightly attenuated these associations, but the association with late perimenopause remained statistically significant (P=0.001). Each SD lower log estradiol value was associated with a 0.07-mm larger adventitial diameter after adjustment for traditional cardiovascular risk factors (P=0.023), whereas other endogenous hormones showed no associations. Intima-media thickness values were not significantly associated with menopausal status or endogenous sex hormones after adjustment for age. CONCLUSIONS The menopausal transition and declining estrogen levels are associated with alterations of the peripheral vasculature, which may help to explain the increased risk of cardiovascular disease with postmenopause.

Url: http://www.ncbi.nlm.nih.gov/pubmed/18209686

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2874195

User Submitted?: No

Authors: Wildman, Rachel P; Colvin, Alicia B; Powell, Lynda H; Matthews, Karen A; Everson-Rose, Susan A; Hollenberg, Steven M; Johnston, Janet M; Sutton-Tyrrell, Kim

Periodical (Full): Menopause (New York, N.Y.)

Issue: 3

Volume: 15

Pages: 414-21

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop