MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Socioeconomic Status and Childhood Cancer Incidence: A Population-Based Multilevel Analysis

Citation Type: Journal Article

Publication Year: 2018

ISSN: 14766256

DOI: 10.1093/aje/kwx322

PMID: 29036606

Abstract: The etiology of childhood cancers remains largely unknown, especially regarding environmental and behavioral risk factors. Unpacking the association between socioeconomic status (SES) and incidence may offer insight into such etiology. We tested associations between SES and childhood cancer incidence in a population-based case-cohort study (source cohort: Minnesota birth registry, 1989-2014). Cases, ages 0-14 years, were linked from the Minnesota Cancer Surveillance System to birth records through probabilistic record linkage. Controls were 4:1 frequency matched on birth year (2,947 cases and 11,907 controls). We tested associations of individual-level (maternal education) and neighborhood-level (census tract composite index) SES using logistic mixed models. In crude models, maternal education was positively associated with incidence of acute lymphoblastic leukemia (odds ratio (OR) = 1.10, 95% confidence interval (CI): 1.02, 1.19), central nervous system tumors (OR = 1.12, 95% CI: 1.04, 1.21), and neuroblastoma (OR = 1.15, 95% CI: 1.02, 1.30). Adjustment for established risk factors-including race/ethnicity, maternal age, and birth weight-substantially attenuated these positive associations. Similar patterns were observed for neighborhood-level SES. Conversely, higher maternal education was inversely associated with hepatoblastoma incidence (adjusted OR = 0.70, 95% CI: 0.51, 0.98). Overall, beyond the social patterning of established demographic and pregnancy-related exposures, SES is not strongly associated with childhood cancer incidence.

Url: http://www.ncbi.nlm.nih.gov/pubmed/29036606

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5928452

Url: https://academic.oup.com/aje/article/187/5/982/4258818

User Submitted?: No

Authors: Kehm, Rebecca D.; Spector, Logan G.; Poynter, Jenny N.; Vock, David M.; Osypuk, Theresa L.

Periodical (Full): American Journal of Epidemiology

Issue: 5

Volume: 187

Pages: 982-991

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop