MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Genetic susceptibility variants for chronic lymphocytic leukemia

Citation Type: Book, Whole

Publication Year: 2010

ISBN: 1538-7755 (Electronic)\r1055-9965 (Linking)

ISSN: 1055-9965

DOI: 10.1158/1055-9965.EPI-09-1217

PMID: 20332261

Abstract: BACKGROUND: There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population. METHODS: We evaluated the association of these variants, or variants in linkage disequilibrium with these variants, with CLL risk in an independent sample of 438 CLL cases and 328 controls. RESULTS: Of these seven single nucleotide polymorphisms (SNP), six had P trend < 0.05 and had estimated odds ratios (OR) that were strikingly comparable to those of the previous study. Associations were seen for rs9378805 [OR, 1.47; 95% confidence intervals (CI), 1.19-1.80; P trend = 0.0003] near IRF4 and rs735665 near GRAMD1B (OR, 1.47; 95% CI, 1.14-1.89; P trend = 0.003). However, no associations (P > 0.05) were found for rs11083846, nor were any found for any SNP in linkage disequilibrium with rs11083846. CONCLUSIONS: Our results confirm the previous findings and further support the role of a genetic basis in the etiology of CLL; however, more research is needed to elucidate the causal SNP(s) and the potential manner in which these SNPs or linked SNPs function in CLL pathogenesis.

Url: http://www.ncbi.nlm.nih.gov/pubmed/20332261

User Submitted?: No

Authors: Slager, Susan L.; Goldin, Lynn R.; Strom, Sara S.; Lanasa, Mark C.; Spector, Logan G.; Rassenti, Laura Z.; Leis, Jose F.; Camp, Nicola J.; Kay, Neil E.; Vachon, Celine M.; Glenn, Martha; Weinberg, J. Brice; Rabe, Kari G.; Cunningham, J M; Achenbach, Sara J.; Hanson, Curtis A.; Marti, Gerald E.; Call, Timothy G.; Caporaso, Neil E.; Cerhan, James R

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Pages: 1098-1102

Volume: 19

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