MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study

Citation Type: Journal Article

Publication Year: 2021

ISSN: 1079-5006

DOI: 10.1093/GERONA/GLAB287

Abstract: BACKGROUND: Although a few studies reported an association between varicose veins and physical function, this potentially bi-directional association has not been systematically evaluated in the general population. METHODS: In 5,580 participants (aged 71-90 years) from the Atherosclerosis Risk in Communities study, varicose veins were identified in outpatient and inpatient administrative data prior to (prevalent cases) and after (incident cases) visit 5 (2011-2013). Physical function was evaluated by the Short Physical Performance Battery (SPPB, score ranging from 0-12). We evaluated 1) cross-sectional association between prevalent varicose veins and physical function, 2) association of prevalent varicose veins with subsequent changes in physical function from visit 5 to visits 6 (2016-2017) and 7 (2018-2019), 3) association of physical function at visit 5 with incident varicose veins during a median follow-up of 3.6 years (105 incident varicose veins among 5,350 participants without prevalent cases at baseline). RESULTS: At baseline, varicose veins were recognized in 230 (4.1%) participants and cross-sectionally associated with reduced physical function. Longitudinally, prevalent varicose veins were not significantly associated with a decline in SPPB over time. In contrast, a low SPPB ≤6 was associated with a greater incidence of varicose veins compared to SPPB ≥10 (adjusted hazard ratio 2.13 [95% CI 1.19, 3.81]) . CONCLUSION: In community-dwelling older adults, varicose veins and low physical function were associated cross-sectionally. Longitudinally, low physical function was a risk factor for incident varicose veins, but not vice versa. Our findings suggest an etiological contribution of low physical function to incident varicose veins.

Url: https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glab287/6381177

User Submitted?: No

Authors: Mok, Yejin; Ishigami, Junichi; Sang, Yingying; Kucharska-Newton, Anna M; Salameh, Maya; Schrack, Jennifer A; Palta, Priya; Coresh, Josef; Windham, B Gwen; Lutsey, Pamela L; Folsom, Aaron R; Matsushita, Kunihiro

Periodical (Full): The Journals of Gerontology: Series A

Issue:

Volume: XX, No. XX

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IPUMS NHGIS NAPP IHIS ATUS Terrapop