MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL

Citation Type: Book, Whole

Publication Year: 2011

ISBN: 1476-5551 (Electronic)\r0887-6924 (Linking)

ISSN: 08876924

DOI: 10.1038/leu.2011.117

PMID: 21617698

Abstract: Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals. Most MBL have an immunophenotype similar to chronic lymphocytic leukemia (CLL), and 'CLL-like' MBL is a precursor to CLL. We used flow cytometry to identify MBL from unaffected members of CLL kindreds. We identified 101 MBL cases from 622 study subjects; of these, 82 individuals with MBL were further characterized. In all, 91 unique MBL clones were detected: 73 CLL-like MBL (CD5(+)CD20(dim)sIg(dim)), 11 atypical MBL (CD5(+)CD20(+)sIg(+)) and 7 CD5(neg) MBL (CD5(neg)CD20(+)sIg(neg)). Extended immunophenotypic characterization of these MBL subtypes was performed, and significant differences in cell surface expression of CD23, CD49d, CD79b and FMC-7 were observed among the groups. Markers of risk in CLL such as CD38, ZAP70 and CD49d were infrequently expressed in CLL-like MBL, but were expressed in the majority of atypical MBL. Interphase cytogenetics was performed in 35 MBL cases, and del 13q14 was most common (22/30 CLL-like MBL cases). Gene expression analysis using oligonucleotide arrays was performed on seven CLL-like MBL, and showed activation of B-cell receptor associated pathways. Our findings underscore the diversity of MBL subtypes and further clarify the relationship between MBL and other lymphoproliferative disorders.

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Authors: Lanasa, Mark C.; Allgood, S. D.; Slager, Susan L.; Dave, S. S.; Love, C.; Marti, Gerald E.; Kay, Neil E.; Hanson, Curtis A.; Rabe, Kari G.; Achenbach, Sara J.; Goldin, Lynn R.; Camp, Nicola J.; Goodman, B. K.; Vachon, Celine M.; Spector, Logan G.; Rassenti, Laura Z.; Leis, Jose F.; Gockerman, J. P.; Strom, Sara S.; Call, Timothy G.; Glenn, Martha; Cerhan, James R; Levesque, Christopher; Weinberg, J. Brice; Caporaso, Neil E.

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Pages: 1459-1466

Volume: 25

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