MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Gestational Diabetes Mellitus Is Associated with Differences in Human Milk Hormone and Cytokine Concentrations in a Fully Breastfeeding United States Cohort

Citation Type: Journal Article

Publication Year: 2022

ISSN: 20726643

DOI: 10.3390/NU14030667/S1

PMID: 35277026

Abstract: It is unclear whether gestational diabetes mellitus (GDM) alters breast milk composition. We prospectively examined associations of GDM status with concentrations of six potentially bioactive elements (glucose, insulin, C‐reactive protein (CRP), interleukin‐6 (IL‐6), leptin, and adiponectin) in human milk. These were measured at both 1 and 3 months postpartum in 189 fully breastfeeding women. Mixed‐effects linear regression assessed GDM status‐related differences in these milk bioactives, adjusting for demographics, maternal factors, and diet. At 1 and 3 months postpartum, milk CRP was higher (1.46 ± 0.31 ng/mL; p < 0.001 and 1.69 ± 0.31 ng/mL; p < 0.001) in women with GDM than in women without GDM, whereas milk glucose (−5.23 ± 2.22 mg/dL; p = 0.02 and −5.70 ± 2.22; p = 0.01) and milk insulin (−0.38 ± 0.17 μIU/mL; p = 0.03 and −0.53 ± 0.17; p = 0.003) were lower in women with GDM. These significant associations remained similar after additional adjustment for maternal weight status and its changes. No difference was found for milk IL‐ 6, leptin, and adiponectin. There was no evidence of association between these milk bioactive compounds and 1 h non‐fasting oral glucose challenge serum glucose in the women without GDM. This prospective study provides evidence that potentially bioactive elements of human milk composition are altered in women with GDM.

Url: /pmc/articles/PMC8838140/

Url: /pmc/articles/PMC8838140/?report=abstract

Url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838140/

User Submitted?: No

Authors: Choi, Yuni; Nagel, Emily M.; Kharoud, Harmeet; Johnson, Kelsey E.; Gallagher, Tipper; Duncan, Katy; Kharbanda, Elyse O.; Fields, David A.; Gale, Cheryl A.; Jacobs, Katherine; Jacobs, David R.; Demerath, Ellen W.

Periodical (Full): Nutrients

Issue: 3

Volume: 14

Pages:

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop