MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Opportunities for personalizing colorectal cancer care: an analysis of SEER-medicare data

Citation Type: Journal Article

Publication Year: 2022

ISSN: 1473-1150

DOI: 10.1038/s41397-022-00276-6

Abstract: United States clinical practice guidelines for metastatic colorectal cancer recommend use of medications impacted by genetic variants but do not recommend testing. We analyzed real-world treatment using a cancer registry and claims dataset to explore pharmacogenomic (PGx) medication treatment patterns and characterize exposure. In a cohort of 6957 patients, most (86.9%) were exposed to at least one chemotherapy medication with PGx guidelines. In a cohort of 2223 patients with retail pharmacy claims available, most (79.2%) were treated with at least one non-chemotherapy (79.2%) medication with PGx guidelines. PGx-associated chemotherapy exposure was associated with age, race/ethnicity, educational attainment, and rurality. PGx-associated non-chemotherapy exposure was associated with medication use and comorbidities. The potential impact of PGx testing is large and policies aimed at increasing PGx testing at diagnosis may impact treatment decisions for patients with metastatic colorectal cancer as most patients are exposed to medications with pharmacogenomics implications during treatment.

Url: https://www.nature.com/articles/s41397-022-00276-6

User Submitted?: No

Authors: Rivers, Zachary T.; Parsons, Helen M.; Jacobson, Pamala A.; Kuntz, Karen M.; Farley, Joel F.; Stenehjem, David J.

Periodical (Full): The Pharmacogenomics Journal 2022

Issue:

Volume:

Pages: 1-12

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop