MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers

Citation Type: Journal Article

Publication Year: 2016

ISSN: 1940-6207

DOI: 10.1158/1940-6207.CAPR-15-0380

PMID: 26951845

Abstract: 2-Phenethyl isothiocyanate (PEITC), a natural product found as a conjugate in watercress and other cruciferous vegetables, is an inhibitor of the metabolic activation and lung carcinogenicity of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in F344 rats and A/J mice. We carried out a clinical trial to determine whether PEITC also inhibits the metabolic activation of NNK in smokers. Cigarette smokers were recruited and asked to smoke cigarettes containing deuterium-labeled [pyridine-D4]NNK for an acclimation period of at least 1 week. Then subjects were randomly assigned to one of two arms: PEITC followed by placebo, or placebo followed by PEITC. During the 1-week treatment period, each subject took PEITC (10 mg in 1 mL of olive oil, 4 times per day). There was a 1-week washout period between the PEITC and placebo periods. The NNK metabolic activation ratio [pyridine-D4]hydroxy acid/total [pyridine-D4]NNAL was measured in urine samples to test the hypothesis that PEITC treatment modified NNK metabolism. Eighty-two smokers completed the study and were included in the analysis. Overall, the NNK metabolic activation ratio was reduced by 7.7% with PEITC treatment (P = 0.023). The results of this trial, while modest in effect size, provide a basis for further investigation of PEITC as an inhibitor of lung carcinogenesis by NNK in smokers. Cancer Prev Res; 9(5); 396-405. ©2016 AACR.

Url: http://www.ncbi.nlm.nih.gov/pubmed/26951845

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4854759

Url: http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.1158/1940-6207.CAPR-15-0380

User Submitted?: No

Authors: Yuan, J.-M.; Stepanov, Irina; Murphy, Sharon E.; Wang, Renwei; Allen, S.; Jensen, J.; Strayer, Lori G.; Adams-Haduch, Jennifer; Upadhyaya, P.; Le, C.; Kurzer, M. S.; Nelson, Heather H.; Yu, M. C.; Hatsukami, Dorothy K.; Hecht, Stephen S.

Periodical (Full): Cancer Prevention Research

Issue: 5

Volume: 9

Pages: 396-405

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop