MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Insulin sensitizers may attenuate lean mass loss in older men with diabetes

Citation Type: Journal Article

Publication Year: 2011

ISSN: 1935-5548; 0149-5992

DOI: 10.2337/dc11-1032 [doi]

PMCID: PMC3198278

PMID: 21926282

Abstract: OBJECTIVE: To examine longitudinal changes in total and appendicular lean body mass in older men with impaired fasting glucose (IFG) or diabetes and to determine whether these changes differ by diabetes treatment. RESEARCH DESIGN AND METHODS: A total of 3,752 ambulatory men aged >/= 65 years at baseline participated in a multicenter longitudinal cohort study. Baseline glycemic status was categorized as normoglycemia, IFG, undiagnosed/untreated diabetes, or treated diabetes. Insulin sensitizer medication use (metformin and/or thiazolidinediones) was assessed by prescription medication inventory. The change in total lean and appendicular lean mass was derived from dual X-ray absorptiometry scans taken at baseline and 3.5 +/- 0.7 years later. RESULTS: This male cohort included 1,853 individuals with normoglycemia, 1,403 with IFG, 234 with untreated diabetes, 151 with diabetes treated with insulin sensitizers, and 111 with diabetes treated without insulin sensitizers. Men with untreated diabetes, diabetes treated without insulin sensitizers, or IFG had greater percentage loss in total or appendicular lean mass (P </= 0.05 in comparison to normoglycemic men). There remained a significantly greater percentage loss in appendicular lean mass for these groups even after adjustment for medical comorbidities or lifestyle factors. In contrast, the percentage loss in total or appendicular lean mass in men with diabetes treated with insulin sensitizers was significantly less than that in normoglycemic men in minimally and fully adjusted models. CONCLUSIONS: Skeletal muscle loss was accelerated in men with IFG and diabetes, except when the latter was treated with insulin sensitizers. These findings suggest that insulin sensitizers may attenuate muscle loss.

User Submitted?: No

Authors: Lee, Christine G; Boyko, Edward J; Barrett-Connor, Elizabeth; Miljkovic, I; Hoffman, Andrew R; Everson-Rose, Susan A; Lewis, Cora E; Cawthon, Peggy Mannen; Strotmeyer, Elsa S; Orwoll, Eric S; Osteoporotic Fractures in Men (MrOS) Study Research Group,

Periodical (Full): Diabetes care

Issue: 11

Volume: 34

Pages: 2381-4766

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop