MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Venous thromboembolism mortality and trends in older US adults, 2011–2019

Citation Type: Journal Article

Publication Year: 2023

ISSN: 1096-8652

DOI: 10.1002/AJH.26996

Abstract: Venous thromboembolism (VTE) affects 1.2 million people per year in the United States. With several clinical changes in diagnosis and treatment approaches in the past decade, we evaluated contemporary post-VTE mortality risk profiles and trends. Incident VTE cases were identified from the 2011–2019 Medicare 20% Sample, which is representative of nearly all Americans aged 65 and older. The social deprivation index was linked from public data; race/ethnicity and sex were self-reported. The all-cause mortality risk 30 days and 1 year after incident VTE was calculated in demographic subgroups and by prevalent cancer diagnosis status using model-based standardization. Risks for major cancer types, risk differences by age, sex, race/ethnicity, and socio-economic status (SES), and trends over time are also reported. The all-cause mortality risk among older US adults following incident VTE was 3.1% (95% CI 3.0–3.2) at 30 days and 19.6% (95% CI 19.2–20.1) at 1 year. For cancer-related VTE events, the age-sex-race-standardized risk was 6.0% at 30 days and 34.7% at 1 year. The standardized 30-day and 1-year risks were higher among non-White beneficiaries and among those with low SES. One-year mortality risk decreased 0.28 percentage points per year (95% CI 0.16–0.40) on average across the study period, with no trend observed for 30-day mortality risk. In sum, all-cause mortality risk following incident VTE has decreased slightly in the last decade, but racial and socio-economic disparities persist. Understanding patterns of mortality among demographic subgroups and in cancer-associated events is important for targeting efforts to improve VTE management.

Url: https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.26996

Url: https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.26996

Url: https://onlinelibrary.wiley.com/doi/10.1002/ajh.26996

User Submitted?: No

Authors: Giorgio, Katherine; Walker, Rob F.; MacLehose, Richard F.; Adrianzen-Herrera, Diego; Wang, Wendy; Alonso, Alvaro; Zakai, Neil A.; Lutsey, Pamela L.

Periodical (Full): American Journal of Hematology

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