Full Citation

Title: Role of APOE ε4 Allele and Incident Stroke on Cognitive Decline and Mortality.

Citation Type: Journal Article

Publication Year: 2016

ISBN:

ISSN: 1546-4156

DOI: 10.1097/WAD.0000000000000173

NSFID:

PMCID:

PMID: 27849638

Abstract: BACKGROUND The apolipoprotein E (APOE) ε4 allele and stroke increase the risk of cognitive decline. However, the association of the APOE ε4 allele before and after stroke is not well understood. METHODS Using a prospective sample of 3444 (66% African Americans, 61% females, mean age=71.9 y) participants, we examined cognitive decline relative to stroke among those with and without the APOE ε4 allele. RESULTS In our sample, 505 (15%) had incident stroke. Among participants without stroke, the ε4 allele was associated with increased cognitive decline compared to noncarriers (0.080 vs. 0.036 units/year; P<0.0001). Among participants without the ε4 allele, cognitive decline increased significantly after stroke compared to before stroke (0.115 vs. 0.039 units/year; P<0.0001). Interestingly, cognitive decline before and after stroke was not significantly different among those with the ε4 allele (0.091 vs. 0.102 units/year; P=0.32). Poor cognitive function was associated with higher risk of stroke (hazard ratio=1.41, 95% confidence interval, 1.25-1.58), but the APOE ε4 allele was not (P=0.66). The APOE ε4 allele, cognitive function, and incident stroke were associated with mortality. CONCLUSIONS The association of stroke with cognitive decline appears to differ by the presence of the APOE ε4 allele, but no such interaction was observed for mortality.

Url: http://www.ncbi.nlm.nih.gov/pubmed/27849638

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5117953

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Authors: Rajan, Kumar B; Aggarwal, Neelum T; Schneider, Julie A; Wilson, R. Storey; Everson-Rose, Susan A; Evans, Denis A

Periodical (Full): Alzheimer disease and associated disorders

Issue: 4

Volume: 30

Pages: 318-323

Countries: