Full Citation
Title: Childhood cancer incidence in relation to sunlight exposure
Citation Type: Book, Whole
Publication Year: 2011
ISBN: 1532-1827 (Electronic)$\$n0007-0920 (Linking)
ISSN: 00070920
DOI: 10.1038/sj.bjc.6606015
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PMCID:
PMID: 21102587
Abstract: BACKGROUND: There is increasing interest in the possible association between cancer incidence and vitamin D through its role as a regulator of cell growth and differentiation. Epidemiological studies in adults and one paediatric study suggest an inverse association between sunlight exposure and cancer incidence.$\$n$\$nMETHODS: We carried out an ecological study using childhood cancer registry data and two population-level surrogates of sunlight exposure, (1) latitude of the registry city or population centroid of the registry nation and (2) annual solar radiation. All models were adjusted for nation-level socioeconomic status using socioeconomic indicators.$\$n$\$nRESULTS: Latitude and radiation were significantly associated with cancer incidence, and the direction of association was consistent between the surrogates. Findings were not consistent across tumour types.$\$n$\$nCONCLUSION: Our ecological study offers some evidence to support an association between sunlight exposure and risk of childhood cancer.
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Authors: Musselman, Jessica R B; Spector, Logan G.
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Pages: 214-220
Volume: 104
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