MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: The association between sex and most childhood cancers is not mediated by birthweight

Citation Type: Journal Article

Publication Year: 2018

ISSN: 18777821

DOI: 10.1016/j.canep.2018.09.002

PMCID: PMC6289597

PMID: 30248472

Abstract: BACKGROUND Male sex is associated with an increased risk of childhood cancer as is high birthweight. Given that sex determination precedes birthweight we conducted a mediation analysis to estimate the direct effect of sex in association with childhood cancer tumor type with birthweight as the mediator. METHODS Cases (n = 12,632) and controls (n = 64,439) (ages 0-14 years) were identified from population-based cancer and birth registries in Minnesota, New York, and Washington states (1970-2014). An inverse odds weighting (IOW) mediation analysis was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) as the measure of association between sex and cancer. RESULTS A significant indirect effect was observed for sex and lymphoid leukemia, mediated by birthweight (indirectOR: 1.03; 95% CI: 1.02-1.04). We observed significant direct effects for male sex and lymphoid leukemia (directOR: 1.16; 95% CI: 1.08-1.25), Hodgkin lymphoma (directOR: 1.48; 95% CI: 1.22-1.81), Burkitt lymphoma (directOR: 5.02; 95% CI: 3.40-7.42), other non-Hodgkin lymphoma (directOR: 1.42; 95% CI: 1.18-1.70), intracranial embryonal tumors (directOR: 1.49; 95% CI: 1.26-1.76), hepatoblastoma (directOR: 1.90; 95% CI: 1.40-2.59), and rhabdomyosarcoma (directOR: 1.47; 95% CI: 1.19-1.81). There were also inverse associations for extracranial GCTs (directOR: 0.41; 95% CI: 0.26-0.63) and thyroid carcinoma (directOR: 0.35; 95% CI: 0.25-0.50). CONCLUSION Significant direct effects for sex and numerous childhood cancer types suggests sex-specific factors such as differences in gene expression from the autosomes or the X chromosome, rather than birthweight, may underlie sex differences in tumor risk.

Url: http://www.ncbi.nlm.nih.gov/pubmed/30248472

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6289597

Url: https://linkinghub.elsevier.com/retrieve/pii/S1877782118303151

User Submitted?: No

Authors: Williams, Lindsay A.; Richardson, Michaela R.; Kehm, Rebecca D.; McLaughlin, Colleen C.; Mueller, Beth A.; Chow, Eric J.; Spector, Logan G.

Periodical (Full): Cancer Epidemiology

Issue:

Volume: 57

Pages: 7-12

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop