Full Citation
Title: Plasma neuronal growth regulator 1 may link physical activity to reduced risk of type 2 diabetes: a proteome-wide study of ARIC participants
Citation Type: Journal Article
Publication Year: 2023
ISBN:
ISSN: 1939-327X
DOI: 10.2337/DB23-0383
NSFID:
PMCID:
PMID: 37935012
Abstract: <p>Habitual physical activity (PA) impacts the plasma proteome and reduces the risk of developing type 2 diabetes (T2D). Using a large-scale proteome-wide approach in Atherosclerosis Risk in Communities Study participants, we aimed to identify plasma proteins associated with PA and determine which of these may be causally related to lower T2D risk. PA was associated with 92 plasma proteins in discovery (p&lt;1.01x10−5), and 40 remained significant in replication (p&lt;5.43x10−4). Eighteen of these proteins were independently associated with incident T2D (p&lt;1.25x10−3) including neuronal growth regulator 1 (NeGR1) (HR per SD: 0.85; p-value=7.5x10−11). Two-sample Mendelian randomization inverse variance weighted analysis indicated that higher NeGR1 reduces T2D risk (OR per SD: 0.92; p=0.03) and was consistent with MR-Egger, weighted median, and weighted mode sensitivity analyses. A stronger association was observed for the single cis-acting NeGR1 genetic variant (OR per SD: 0.80; p=6.3x10−5). Coupled with previous evidence that low circulating NeGR1 levels promote adiposity, its association with PA and potential causal role in T2D shown here suggest that NeGR1 may link PA exposure with metabolic outcomes. Further research is warranted to confirm our findings and examine the interplay of PA, NeGR1, adiposity, and metabolic health.</p>
Url: https://pubmed.ncbi.nlm.nih.gov/37935012/
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Authors: Steffen, Brian T.; McDonough, Daniel J.; Pankow, James S.; Tang, Weihong; Rooney, Mary R.; Demmer, Ryan T.; Lutsey, Pamela L.; Guan, Weihua; Gabriel, Kelley Pettee; Palta, Priya; Moser, Ethan D.; Pereira, Mark A.
Periodical (Full): Diabetes
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