MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: The Association of Kidney Function with Plasma Amyloid-β Levels and Brain Amyloid Deposition

Citation Type: Journal Article

Publication Year: 2023

ISSN: 1387-2877

DOI: 10.3233/JAD-220765

Abstract: <p>Background: Reduced kidney function is related to brain atrophy and higher risk of dementia. It is not known whether kidney impairment is associated with higher levels of circulating amyloid-β and brain amyloid-β deposition, which could contribute to elevated risk of dementia. Objective: To investigate whether kidney impairment is associated with higher levels of circulating amyloid-β and brain amyloid-β deposition. Methods: This cross-sectional study was performed within the community–based Atherosclerosis Risk in Communities (ARIC) Study cohort. We used estimated glomerular filtration rate (eGFR) based on serum creatinine and cystatin C levels and urine albumin-to-creatinine ratio (ACR) to assess kidney function. Amyloid positivity was defined as a standardized uptake value ratios &gt;  1.2 measured with florbetapir positron emission tomography (PET) (n = 340). Plasma amyloid-β 1 - 40 and amyloid-β 1 - 42 were measured using a fluorimetric bead-based immunoassay (n = 2,569). Results: Independent of demographic and cardiovascular risk factors, a doubling of ACR was associated with 1.10 (95% CI: 1.01,1.20) higher odds of brain amyloid positivity, but not eGFR (odds ratio per 15 ml/min/1.73 m2 lower eGFR: 1.08; 95% CI: 0.95,1.23). A doubling of ACR was associated with a higher level of plasma amyloid-β 1 - 40 (standardized difference: 0.12; 95% CI: 0.09,0.14) and higher plasma amyloid-β 1 - 42 (0.08; 95% CI: 0.05,0.10). Lower eGFR was associated with higher plasma amyloid-β 1 - 40 (0.36; 95% CI: 0.33,0.39) and higher amyloid-β 1 - 42 (0.32; 95% CI: 0.29,0.35). Conclusion: Low clearance of amyloid-β and elevated brain amyloid positivity may link impaired kidney function with elevated risk of dementia. kidney function should be considered in interpreting amyloid biomarker results in clinical and research setting.</p>

Url: https://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-220765

User Submitted?: No

Authors: Sedaghat, Sanaz; Ji, Yuekai; Hughes, Timothy M.; Coresh, Josef; Grams, Morgan E.; Folsom, Aaron R.; Sullivan, Kevin J.; Murray, Anne M.; Gottesman, Rebecca F.; Mosley, Thomas H.; Lutsey, Pamela L.

Periodical (Full): Journal of Alzheimer's Disease

Issue: Preprint

Volume: Preprint

Pages: 1-11

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop