Full Citation

Title: Genome-wide association study identifies two susceptibility loci for osteosarcoma

Citation Type: Book, Whole

Publication Year: 2013

ISBN: 1061-4036

ISSN: 10614036

DOI: 10.1038/ng.2645

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PMCID:

PMID: 23727862

Abstract: Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10(-9)) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10(-8) and 2.9 × 10(-7), respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.

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Authors: Savage, Sharon A.; Mirabello, Lisa; Wang, Zhaoming; Gastier-Foster, Julie M.; Gorlick, Richard; Khanna, Chand; Flanagan, Adrienne M.; Tirabosco, Roberto; Andrulis, Irene L.; Wunder, Jay S.; Gokgoz, Nalan; Patiño-García, Ana; Sierrasesúmaga, Luis; Lecanda, Fernando; Kurucu, Nilgün; Ilhan, Inci Ergurhan; Sari, Neriman; Serra, Massimo; Hattinger, Claudia; Picci, Piero; Spector, Logan G.; Barkauskas, Donald A.; Marina, Neyssa; De Toledo, Silvia Regina Caminada; Petrilli, Antonio S.; Amary, Maria Fernanda; Halai, Dina; Thomas, David M.; Douglass, Chester; Meltzer, Paul S.; Jacobs, Kevin; Chung, Charles C.; Berndt, Sonja I.; Purdue, Mark P.; Caporaso, Neil E.; Tucker, Margaret; Rothman, Nathaniel; Landi, Maria Teresa; Silverman, Debra T.; Kraft, Peter; Hunter, David J.; Malats, Nuria; Kogevinas, Manolis; Wacholder, Sholom; Troisi, Rebecca; Helman, Lee; Fraumeni, Joseph F.; Yeager, Meredith; Hoover, Robert N.; Chanock, Stephen J.

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Pages: 799-803

Volume: 45

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