MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites

Citation Type: Journal Article

Publication Year: 2024

ISBN: 1111111111

ISSN: 1932-6203

DOI: 10.1371/JOURNAL.PONE.0305004

Abstract: Objective Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse birth and developmental outcomes in children. We aimed to describe prenatal PAH exposures in a large, multisite U.S. consortium. Methods We measured 12 mono-hydroxylated metabolites (OH-PAHs) of 7 PAHs (naphthalene, fluorene, phenanthrene, pyrene, benzo(c)phenanthrene, chrysene, benz(a)anthracene) in mid-pregnancy urine of 1,892 pregnant individuals from the ECHO PATHWAYS consortium cohorts: CANDLE (n = 988; Memphis), TIDES (n = 664; Minneapolis, Rochester, San Francisco, Seattle) and GAPPS (n = 240; Seattle and Yakima, WA). We described concentrations of 8 OH-PAHs of non-smoking participants (n = 1,695) by site, socioeconomic characteristics, and pregnancy stage (we report intraclass correlation coefficients (ICC) for n = 677 TIDES participants). Results Exposure to the selected PAHs was ubiquitous at all sites. 2-hydroxynaphthalene had the highest average concentrations at all sites. CANDLE had the highest average concentrations of most metabolites. Among non-smoking participants, we observed some patterns by income, education, and race but these were not consistent and varied by site and metabolite. ICCs of repeated OH-PAH measures from TIDES participants were ≤ 0.51. Conclusion In this geographically-diverse descriptive analysis of U.S. pregnancies, we observed ubiquitous exposure to low molecular weight PAHs, highlighting the importance of better understanding PAH sources and their pediatric health outcomes attributed to early life PAH exposure.

Url: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0305004

User Submitted?: No

Authors: Masterson, Erin E.; Riederer, Anne M.; Loftus, Christine T.; Wallace, Erin R.; Szpiro, Adam A.; Simpson, Christopher D.; Muralidharan, Revathi; Trasande, Leonardo; Barrett, Emily S.; Nguyen, Ruby H. N.; Kannan, Kurunthachalam; Robinson, Morgan; Swan, Shanna; Mason, W. Alex; Bush, Nicole R.; Sathyanarayana, Sheela; LeWinn, Kaja Z.; Karr, Catherine J.

Periodical (Full): PLOS ONE

Issue: 7

Volume: 19

Pages: e0305004

Countries:

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