MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: An analysis of measures of effect size by age of onset in cancer genomewide association studies

Citation Type: Book, Whole

Publication Year: 2013

ISSN: 10452257

DOI: 10.1002/gcc.22081

Abstract: Many of the genetic variants identified via genome-wide association studies (GWAS) appear to have larger parameter estimates for younger onset cancers compared with adult onset cancers. We used data from the National Human Genome Research Institute (NHRGI) Catalog of Published GWAS to test the hypothesis that the magnitude of the parameter estimates is larger in younger onset compared to adult onset cancers. We found that the odds ratios in individuals categorized as childhood or young adult cancers were significantly higher than the odds ratios in individuals with adult cancers. The presence of larger effect sizes may mean that the variants associated with younger onset cancers explain a greater proportion of the population attributable risk estimates than the SNPs associated with adult onset cancers, which could improve early detection, treatment, and/or prevention. © 2013 Wiley Periodicals, Inc.

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Authors: Raynor, L. A.; Pankratz, Nathan; Spector, Logan G.

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Pages: 855-859

Volume: 52

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IPUMS NHGIS NAPP IHIS ATUS Terrapop