MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain

Citation Type: Journal Article

Publication Year: 2016

ISSN: 0003-4819

DOI: 10.7326/M15-2877

PMID: 27111355

Abstract: Systematic reviews (SRs) have the potential to contribute uniquely to the evaluation of sex and gender differences (termed "sex effects"). This article describes the reporting of sex effects by SRs on interventions for depression, type 2 diabetes mellitus, and chronic pain conditions (chronic low back pain, knee osteoarthritis, and fibromyalgia). It includes SRs published since 1 October 2009 that evaluate medications, behavioral interventions, exercise, quality improvement, and some condition-specific treatments. The reporting of sex effects by primary randomized, controlled trials is also examined. Of 313 eligible SRs (86 for depression, 159 for type 2 diabetes mellitus, and 68 for chronic pain), few (n = 29) reported sex effects. Most SRs reporting sex effects used metaregression, whereas 9 SRs used subgroup analysis or individual-patient data meta-analysis. The proportion of SRs reporting the sex distribution of primary studies varied from a low of 31% (n = 8) for low back pain to a high of 68% (n = 23) for fibromyalgia. Primary randomized, controlled trials also infrequently reported sex effects, and most lacked an adequate sample size to examine them. Therefore, all SRs should report the proportion of women enrolled in primary studies and evaluate sex effects using appropriate methods whenever power is adequate.

Url: http://www.ncbi.nlm.nih.gov/pubmed/27111355

Url: http://annals.org/article.aspx?doi=10.7326/M15-2877

User Submitted?: No

Authors: Duan-Porter, Wei; Goldstein, Karen M.; McDuffie, Jennifer R.; Hughes, Jaime M.; Clowse, Megan E.B.; Klap, Ruth S.; Masilamani, Varsha; Allen LaPointe, Nancy M.; Nagi, Avishek; Gierisch, Jennifer M.; Williams, John W.

Periodical (Full): Annals of Internal Medicine

Issue: 3

Volume: 165

Pages: 184

Countries:

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