MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Do pregnancy characteristics contribute to rising childhood cancer incidence rates in the United States?

Citation Type: Journal Article

Publication Year: 2018

ISSN: 15455009

DOI: 10.1002/pbc.26888

PMID: 29160610

Abstract: Background: Since 1975, childhood cancer incidence rates have gradually increased in theUnited States; however, few studies have conducted analyses across time to unpack this temporal rise. The aim of this studywas to test the hypothesis that increasing cancer incidence rates are due to secular trends in pregnancy characteristics that are established risk factors for childhood cancer incidence including older maternal age, higher birthweight, and lower birth order.We also consid- ered temporal trends in sociodemographic characteristics including race/ethnicity and poverty. Procedure:We conducted a time series county-level ecologic analysis using linked population- based data from Surveillance, Epidemiology, and EndResults cancer registries (1975–2013), birth data from the National Center for Health Statistics (1970–2013), and sociodemographic data from theUSCensus (1970–2010).We estimated unadjusted and adjusted average annual percent changes (AAPCs) in incidence of combined (all diagnoses) and individual types of cancer among children, ages 0–4 years, from Poisson mixed models. Results: There was a statistically significant unadjusted temporal rise in incidence of combined childhood cancers (AAPC = 0.71%; 95% CI = 0.55–0.86), acute lymphoblastic leukemia (0.78%; 0.49–1.07), acute myeloid leukemia (1.86%; 1.13–2.59), central nervous system tumors (1.31%; 0.94–1.67), and hepatoblastoma (2.70%; 1.68–3.72). Adjustment for county-level maternal age reduced estimated AAPCs between 8% (hepatoblastoma) and 55% (combined).However, adjust- mentfor other county characteristics did not attenuate AAPCs, andAAPCsremained significantly above0%in models fully adjusted for county-level characteristics. Conclusion: Although rising maternal age may account for some of the increase in childhood cancer incidence over time, other factors, not considered in this analysis, may also contribute to temporal trends.

Url: http://doi.wiley.com/10.1002/pbc.26888

User Submitted?: No

Authors: Kehm, Rebecca D.; Osypuk, Theresa L.; Poynter, Jenny N.; Vock, David M.; Spector, Logan G.

Periodical (Full): Pediatric Blood & Cancer

Issue: 3

Volume: 65

Pages: e26888

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop