MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium

Citation Type: Journal Article

Publication Year: 2023

ISSN: 1097-0215

DOI: 10.1002/IJC.34720

Abstract: <p>Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire‐based and three registry‐based case‐control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia. Our analyses included acute lymphoblastic leukemia (ALL, n = 13 115) and acute myeloid leukemia (AML, n = 2120) cases, along with 46 172 controls. We used the false discovery rate to account for multiple comparisons. In the questionnaire‐based studies, the prevalence of birth defects was 5% among cases vs 4% in controls, whereas, in the registry‐based studies, the prevalence was 11% among cases vs 7% in controls. In pooled adjusted analyses, there were several notable associations, including (1) digestive system defects and ALL (OR = 2.70, 95% CI: 1.46‐4.98); (2) congenital anomalies of the heart and circulatory system and AML (OR = 2.86, 95% CI: 1.81‐4.52) and (3) nervous system defects and AML (OR = 4.23, 95% CI: 1.50‐11.89). Effect sizes were generally larger in registry‐based studies. Overall, our results could point to novel genetic and environmental factors associated with birth defects that could also increase leukemia susceptibility. Additionally, differences between questionnaire‐ and registry‐based studies point to the importance of complementary sources of birth defect phenotype data when exploring these associations.</p>

Url: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.34720

Url: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34720

Url: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34720

User Submitted?: No

Authors: Lupo, Philip J; Chambers, Tiffany M; Mueller, Beth A; Clavel, Jacqueline; Dockerty, John D; Doody, David R; Erdmann, Friederike; Ezzat, Sameera; Filippini, Tommaso; Hansen, Johnni; Heck, Julia E; Infante-Rivard, Claire; Kang, Alice Y; Magnani, Corrado; Malagoli, Carlotta; Metayer, Catherine; Bailey, Helen D; Mora, Ana M; Ntzani, Evangelia; Th Petridou, Eleni; Pombo-de-Oliveira, Maria S; Rashed, Wafaa M; Roman, Eve; Schüz, Joachim; Wesseling, Catharina; Spector, Logan G; Scheurer, Michael E; Philip Lupo, Correspondence J

Periodical (Full): International Journal of Cancer

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