MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: An exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation outcomes

Citation Type: Book, Whole

Publication Year: 2015

ISSN: 15236536

DOI: 10.1016/j.bbmt.2014.09.023

PMID: 25300867

Abstract: Certain mitochondrial haplotypes (mthaps) are associated with disease, possibly through differences in oxidative phosphorylation and/or immunosurveillance. We explored whether mthaps are associated with allogeneic hematopoietic cell transplantation (HCT) outcomes. Recipient (n= 437) and donor (n= 327) DNA were genotyped for common European mthaps (H, J, U, T, Z, K, V, X, I, W, and K2). HCT outcomes for mthap matched siblings (n= 198), all recipients, and all donors were modeled using relative risks (RR) and 95% confidence intervals and compared with mthap H, the most common mitochondrial haplotypes. Siblings with I and V were significantly more likely to die within 5 years (RR= 3.0; 95% confidence interval [CI], 1.2 to 7.9; and RR= 4.6; 95% CI, 1.8 to 12.3, respectively). W siblings experienced higher acute graft-versus-host disease (GVHD) grades II to IV events (RR= 2.1; 95% CI, 1.1 to 2.4) with no events for those with K or K2. Similar results were observed for all recipients combined, although J recipients experienced lower GVHD and higher relapse. Patients with I donors had a 2.7-fold (1.2 to 6.2) increased risk of death in 5 years, whereas few patients with K2 or W donors died. No patients with K2 donors and few patients with U donors relapsed. Mthap may be an important consideration in HCT outcomes, although validation and functional studies are needed. If confirmed, it may be feasible to select donors based on mthap to increase positive or decrease negative outcomes.

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Authors: Ross, Julie A.; Tolar, Jakub; Spector, Logan G.; DeFor, Todd; Lund, Troy C.; Weisdorf, Daniel J.; Langer, Erica K.; Hooten, Anthony J.; Thyagarajan, Bharat; Gleason, Michelle K.; Wagner, John E.; Robien, Kim; Verneris, Michael R.

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Pages: 81-88

Volume: 21

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