MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition?

Citation Type: Journal Article

Publication Year: 2009

ISSN: 1558-3597

DOI: 10.1016/j.jacc.2009.10.009

PMID: 20082925

Abstract: OBJECTIVES This prospective study examined whether changes in traditional and novel coronary heart disease (CHD) risk factors are greater within a year of the final menstrual period (FMP), relative to changes that occur before or after that interval, in a multiethnic cohort. BACKGROUND Understanding the influence of menopause on CHD risk remains elusive and has been evaluated primarily in Caucasian samples. METHODS SWAN (Study of Women's Health Across the Nation) is a prospective study of the menopausal transition in 3,302 minority (African American, Hispanic, Japanese, or Chinese) and Caucasian women. After 10 annual examinations, 1,054 women had achieved an FMP not due to surgery and without hormone therapy use before FMP. Measured CHD risk factors included lipids and lipoproteins, glucose, insulin, blood pressure, fibrinogen, and C-reactive protein. We assessed which of 2 models provided a better fit with the observed risk factor changes over time in relation to the FMP: a linear model, consistent with chronological aging, or a piecewise linear model, consistent with ovarian aging. RESULTS Only total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B demonstrated substantial increases within the 1-year interval before and after the FMP, consistent with menopause-induced changes. This pattern was similar across ethnic groups. The other risk factors were consistent with a linear model, indicative of chronological aging. CONCLUSIONS Women experience a unique increase in lipids at the time of the FMP. Monitoring lipids in perimenopausal women should enhance primary prevention of CHD.

Url: http://www.ncbi.nlm.nih.gov/pubmed/20082925

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2856606

User Submitted?: No

Authors: Matthews, Karen A; Crawford, Sybil L; Chae, Claudia U; Everson-Rose, Susan A; Sowers, Mary Fran; Sternfeld, Barbara; Sutton-Tyrrell, Kim

Periodical (Full): Journal of the American College of Cardiology

Issue: 25

Volume: 54

Pages: 2366-73

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop