MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Parental Age and Risk of Infant Leukaemia: A Pooled Analysis

Citation Type: Book, Whole

Publication Year: 2017

ISSN: 13653016

DOI: 10.1111/ppe.12412

PMID: 28940632

Abstract: BackgroundInfant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. MethodsWe evaluated the relationship between parental age and IL in a case-control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases {[}219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45392 controls born during 1981-2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. ResultsInfants with mothers' age 40years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). ConclusionThis study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.

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Authors: Marcotte, Erin L.; Druley, Todd E.; Johnson, Kimberly J.; Richardson, Michaela R.; von Behren, Julie; Mueller, Beth A.; Carozza, Susan E.; McLaughlin, Colleen C.; Chow, Eric J.; Reynolds, Peggy; Spector, Logan G.

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Pages: 563-572

Volume: 31

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