Full Citation

Title: A case–control study of childhood brain tumors and fathers’ hobbies: a Children’s Oncology Group study

Citation Type: Book, Whole

Publication Year: 2008

ISBN:

ISSN: 0957-5243

DOI: 10.1007/s10552-008-9189-7

NSFID:

PMCID:

PMID: 18560982

Abstract: A comprehensive case-control study was conducted to evaluate parental\nrisk factors for medulloblastoma (MB) and primitive neuroectodermal\ntumor (PNET). This analysis was conducted to evaluate associations\nbetween fathers' hobbies and risk of their children developing MB/PNET.\nThe hobbies chosen for study were those with similar exposures as\noccupations associated with childhood cancers.\nCases were 318 subjects under six years of age at diagnosis between 1991\nand 1997 and registered with the Children's Cancer Group. An equal\nnumber of controls were selected through random digit dialing and\nindividually matched to cases.\nIn multivariate analyses, a significant association was seen for lawn\ncare with pesticides {[}during pregnancy: odds ratio (OR) = 1.6, 95%\nconfidence interval (CI): 1.0, 2.5; after birth: OR = 1.8, 95% CI: 1.2,\n2.8] and a weak association was seen for stripping paint {[}during\npregnancy: OR = 1.4, 95% CI: 0.8, 2.6; after birth: OR = 1.4, 95% CI:\n0.7, 2.6].\nThis study suggests that household exposures from hobbies, particularly\npesticides, may increase risk of MB/PNET in children; previous research\nhas been mostly limited to occupational exposures.

Url: http://link.springer.com/10.1007/s10552-008-9189-7

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Authors: Rosso, Andrea L.; Hovinga, Mary E.; Rorke-Adams, Lucy B.; Spector, Logan G.; Bunin, Greta R.

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Publisher Location:

Pages: 1201-1207

Volume: 19

Edition:

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