MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States

Citation Type: Journal Article

Publication Year: 2016

ISSN: 1055-9965

DOI: 10.1158/1055-9965.EPI-15-1111

PMID: 26908434

Abstract: BACKGROUND Merkel cell polyomavirus (PyV) is causally related to Merkel cell carcinoma, a rare skin malignancy. Little is known about the serostability of other PyVs over time or associations with cutaneous squamous cell carcinoma (SCC). METHODS As part of a U.S. nested case-control study, antibody response against the PyV VP1 capsid proteins of BK and John Cunningham virus (JC) was measured using multiplex serology on 113 SCC cases and 229 gender, age, and study center-matched controls who had a prior keratinocyte cancer. Repeated serum samples from controls and both pre and postdiagnosis samples from a subset of SCC cases were also tested. Odds ratios (OR) for SCC associated with seropositivity to each PyV type were estimated using conditional logistic regression. RESULTS Among controls, BK and JC seroreactivity was stable over time, with intraclass correlation coefficients of 0.86 for BK and 0.94 for JC. Among cases, there was little evidence of seroconversion following SCC diagnosis. JC seropositivity prior to diagnosis was associated with an elevated risk of SCC (OR = 2.54; 95% CI, 1.23-5.25), and SCC risk increased with increasing quartiles of JC (Ptrend = 0.004) and BK (Ptrend = 0.02) seroreactivity. CONCLUSIONS PyV antibody levels were stable over time and following an SCC diagnosis. A history of PyV infection may be involved in the occurrence of SCC in a population at high risk for this malignancy. IMPACT A single measure of PyV seroreactivity appears a reliable indicator of long-term antibody status, and PyV exposure may be a risk factor for subsequent SCC. Cancer Epidemiol Biomarkers Prev; 25(5); 736-44. ©2016 AACR.

Url: http://www.ncbi.nlm.nih.gov/pubmed/26908434

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4883679

Url: http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-15-1111

User Submitted?: No

Authors: Gossai, Anala; Waterboer, Tim; Nelson, Heather H.; Doherty, J. A.; Michel, Angelika; Willhauck-Fleckenstein, Martina; Farzan, Shohreh F.; Christensen, Brock C.; Hoen, Anne G.; Perry, Ann E.; Pawlita, Michael; Karagas, Margaret R.

Periodical (Full): Cancer Epidemiology Biomarkers & Prevention

Issue: 5

Volume: 25

Pages: 736-744

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop