MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Interactive effects of race and depressive symptoms on calcification in African American and white women.

Citation Type: Journal Article

Publication Year: 2009

ISSN: 1534-7796

DOI: 10.1097/PSY.0b013e31819080e5

PMID: 19188530

Abstract: OBJECTIVE To examine the cross-sectional associations among race, depressive symptoms, and aortic and coronary calcification in a sample of middle-aged women. Depressive symptoms have been associated with atherosclerotic indicators of coronary heart disease (CHD) in white women. Few studies have examined these associations in samples including African American women, or explored whether any observed associations differ by race. METHODS Participants were 508 (38% African American, 62% white) women. Aortic and coronary calcification were measured by electron beam tomography and depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Multivariable linear and logistic regression models were conducted to test associations. RESULTS In linear regression models adjusted for race, depressive symptoms were associated with a greater amount of aortic calcification (beta = 0.03, p = .01), and there was a significant race x depressive symptoms interaction (beta = 0.07, p = .006). Findings for depressive symptoms (odds ratio (OR) = 1.03, 95% Confidence Interval (CI) = 1.0-1.06, p = .07), and the race x depressive symptoms interaction (OR = 1.1, 95% CI = 1.01-1.18, p = .01) were similar in race-adjusted multinomial logistic regression models predicting high levels of aortic calcification. Race-specific models revealed a significant association between depressive symptoms and aortic calcification in African American, but not white women. Additional adjustments for education, study site, and CHD risk factors did not alter these results. Depressive symptoms were not associated with coronary calcification for women of either racial group. CONCLUSIONS African American women may be particularly vulnerable to the effects of depressive symptoms on early atherosclerotic disease.

Url: http://www.ncbi.nlm.nih.gov/pubmed/19188530

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2896037

User Submitted?: No

Authors: Lewis, Tené T; Everson-Rose, Susan A; Colvin, Alicia B; Matthews, Karen A; Bromberger, Joyce T; Sutton-Tyrrell, Kim

Periodical (Full): Psychosomatic medicine

Issue: 2

Volume: 71

Pages: 163-70

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop