Full Citation
Title: The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group
Citation Type: Book, Whole
Publication Year: 2016
ISBN: 1545-5017 (Electronic)\r1545-5009 (Linking)
ISSN: 15455017
DOI: 10.1002/pbc.26065
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PMCID:
PMID: 27198935
Abstract: BackgroundRhabdomyosarcoma (RMS) is a rare, highly malignant tumor\narising from primitive mesenchymal cells that differentiate into\nskeletal muscle. Relatively little is known about RMS susceptibility.\nBased on growing evidence regarding the role of early immunologic\nchallenges on RMS development, we evaluated the role of infections and\nimmunizations on this clinically significant pediatric malignancy.\nProcedureRMS cases (n = 322) were enrolled from the third trial\ncoordinated by the Intergroup Rhabdomyosarcoma Study Group.\nPopulation-based controls (n = 322) were pair matched to cases on race,\nsex, and age. The following immunizations were assessed: diphtheria,\npertussis, and tetanus (DPT); measles, mumps, and rubella; and oral\npolio vaccine. We also evaluated if immunizations were complete versus\nincomplete. We examined selected infections including chickenpox, mumps,\npneumonia, scarlet fever, rubella, rubeola, pertussis, mononucleosis,\nand lung infections. Conditional logistic regression models were used to\ncalculate an odds ratio (OR) and 95% confidence interval (CI) for each\nexposure, adjusted for maternal education and total annual income.\nResultsIncomplete immunization schedules (OR= 5.30, 95% CI: 2.47-11.33)\nand incomplete DPT immunization (OR = 1.56, 95% CI: 1.06-2.29) were\npositively associated with childhood RMS. However, infections did not\nappear to be associated with childhood RMS.\nConclusionsThis is the largest study of RMS to date demonstrating a\npossible protective effect of immunizations against the development of\nchildhood RMS. Further studies are needed to validate our findings. Our\nfindings add to the growing body of literature, suggesting a protective\nrole of routine vaccinations in childhood cancer and specifically in\nchildhood RMS. (C) 2016 Wiley Periodicals, Inc.
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Authors: Sankaran, Hari; Danysh, Heather E.; Scheurer, Michael E.; Okcu, M. Fatih; Skapek, Stephen X.; Hawkins, Douglas S.; Spector, Logan G.; Erhardt, Erik B.; Grufferman, Seymour; Lupo, Philip J.
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Pages: 1557-1562
Volume: 63
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