Full Citation
Title: Association of Lung Function with Cognitive Decline and Incident Dementia in the Atherosclerosis Risk in Communities Study
Citation Type: Journal Article
Publication Year: 2023
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ISSN: 0002-9262
DOI: 10.1093/AJE/KWAD140
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Abstract: <p>We examined the associations between lung function and incident dementia and cognitive decline in 12,688 participants of the ARIC study who provided lung function measurements in 1990-1992. Cognitive tests were administered up to seven times, and dementia was ascertained through 2019. We used shared parameter models to jointly model proportional hazard models and linear mixed-effect models to estimate lung function-associated dementia rate and cognitive change, respectively. Higher forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were associated with reduced dementia rate (n=2452 developed dementia); hazard ratios per 1L higher FEV1 and FVC were 0.79 (95%CI: 0.71-0.89) and 0.81 (95%CI: 0.74-0.89), respectively. Each 1L higher FEV1 and FVC was associated with 0.08 (95%CI: 0.05-0.12) SD and 0.05 (95%CI: 0.02-0.07) SD attenuation of 30-year cognitive decline, respectively. One percent higher FEV1/FVC was associated with 0.008 (95% CI: 0.004-0.012) SD less cognitive decline. We observed statistical interaction between FEV1 and FVC, suggesting that cognitive declines depended on values of specific FEV1 and FVC (as compared to FEV1, FVC, or FEV1/FVC% models that suggested linear incremental associations). Our findings may have important implications for reducing burden of cognitive decline that is attributable to environmental exposures and associated lung function impairment.</p>
Url: https://dx.doi.org/10.1093/aje/kwad140
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Authors: Shrestha, Srishti; Zhu, Xiaoqian; London, Stephanie J; Sullivan, Kevin J; Lutsey, Pamela L; Windham, Gwen; Griswold, Michael E; Mosley, Thomas H; Dementia, Neurodegenerative
Periodical (Full): American Journal of Epidemiology
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