MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

Citation Type: Journal Article

Publication Year: 2014

ISSN: 0363-6135

DOI: 10.1152/ajpheart.00099.2014

Abstract: Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular disease being a primary risk (96). Childhood cancer survivors have markedly elevated incidences of stroke, congestive heart failure (CHF), coronary artery disease, and valvular disease (96). Their cardiac mortality is 8.2 times higher than expected (93). Anthracyclines are a key component of most curative chemotherapeutic regimens used in pediatric cancer, and approximately half of all childhood cancer patients are exposed to them (78). Numerous epidemiologic and observational studies have linked childhood anthracycline exposure to an increased risk of developing cardiomyopathy and CHF, often decades after treatment. The...

Url: http://www.physiology.org/doi/10.1152/ajpheart.00099.2014

User Submitted?: No

Authors: Lindsey, Merry L.; Lange, Richard A.; Parsons, Helen M.; Andrews, Thomas; Aune, Gregory J.

Periodical (Full): American Journal of Physiology-Heart and Circulatory Physiology

Issue: 10

Volume: 307

Pages: H1379-H1389

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop