Full Citation

Title: Maternal exposure to household chemicals and risk of infant leukemia: A report from the Children's Oncology Group

Citation Type: Book, Whole

Publication Year: 2011

ISBN: 1573-7225 (Electronic)\r0957-5243 (Linking)

ISSN: 09575243

DOI: 10.1007/s10552-011-9798-4

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PMCID:

PMID: 21691732

Abstract: OBJECTIVE: Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to household chemicals and infant acute leukemia. METHODS: We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled household chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We did not find evidence for an association between infant leukemia and eight of nine chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. CONCLUSIONS: Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated.

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Authors: Slater, Megan E.; Linabery, Amy M.; Spector, Logan G.; Johnson, Kimberly J.; Hilden, Joanne M.; Heerema, Nyla A.; Robison, Leslie L.; Ross, Julie A.

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Pages: 1197-1204

Volume: 22

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