MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Longitudinal analysis of serological responses of adults to Helicobacter pylori antigens.

Citation Type: Journal Article

Publication Year: 2010

ISSN: 1537-6613

DOI: 10.1086/655660

PMID: 20698790

Abstract: Because Helicobacter pylori persist for decades in the human stomach, the aim of this study was to examine the long-term course of H. pylori-specific serum immunoglobulin G (IgG) responses with respect to subclass and antigenic target. We studied paired serum samples obtained in 1973 and in 1994 in Vammala, Finland, from 64 healthy H. pylori-positive adults and from other healthy control subjects. H. pylori serum immunoglobulin A, IgG, and IgG subclass responses were determined by antigen-specific enzyme-linked immunosorbent assays. H. pylori-specific IgG1 and IgG4 subtype responses from 47 subjects were similar in 1973 and 1994, but not when compared with unrelated persons. H. pylori-specific IgG1:IgG4 ratios among the participants varied >1000-fold; however, 57 (89.1%) of 64 subjects had an IgG1:IgG4 ratio >1.0, consistent with a predominant IgG1 (Th1) response. Furthermore, ratios in individual hosts were stable over the 21-year period (r = 0.56; P < .001). The immune response to heat shock protein HspA was unchanged in 49 (77%) of the 64 subjects tested; of the 15 whose serostatus changed, all seroconverted and were significantly younger than those whose status did not change. These findings indicate that H. pylori-specific antibody responses are host-specific with IgG1:IgG4 ratios stable over 21 years, IgG1 responses predominating, and HspA seroconversion with aging.

Url: http://www.ncbi.nlm.nih.gov/pubmed/20698790

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2924458

User Submitted?: No

Authors: Perez-Perez, Guillermo I; Maw, Anna M; Feingold-Link, Lani; Gunn, Jennifer; Bowers, Andrea L; Minano, Cecilia; Rautelin, Hilpi; Kosunen, Timo U; Blaser, Martin J

Periodical (Full): The Journal of infectious diseases

Issue: 6

Volume: 202

Pages: 916-23

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop