Full Citation

Title: Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Citation Type: Journal Article

Publication Year: 2020

ISBN:

ISSN: 1750192X

DOI: 10.2217/epi-2019-0276

NSFID:

PMCID:

PMID: 32901515

Abstract: Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

Url: https://pubmed.ncbi.nlm.nih.gov/32901515/

User Submitted?: No

Authors: Justice, Anne E.; Chittoor, Geetha; Gondalia, Rahul; Melton, Phillip E.; Lim, Elise; Grove, Megan L.; Whitsel, Eric A.; Liu, Ching Ti; Cupples, L. Adrienne; Fernandez-Rhodes, Lindsay; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Boerwinkle, Eric; Li, Yun; Demerath, Ellen W.; Heard-Costa, Nancy L.; Levy, Dan; Stewart, James D.; Baccarelli, Andrea A.; Hou, Lifang; Conneely, Karen N.; Mori, Trevor A.; Beilin, Lawrence J.; Huang, Rae Chi; Gordon-Larsen, Penny; Howard, Annie Green; North, Kari E.

Periodical (Full): Epigenomics

Issue: 17

Volume: 12

Pages: 1483-1499

Countries: