MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Family history of cancer and childhood rhabdomyosarcoma: A report from the children's oncology group and the Utah Population Database

Citation Type: Book, Whole

Publication Year: 2015

ISBN: 2045-7634 (Electronic)\r2045-7634 (Linking)

ISSN: 20457634

DOI: 10.1002/cam4.448

PMID: 25809884

Abstract: Relatively little is known about the epidemiology and factors underlying susceptibility to childhood rhabdomyosarcoma (RMS). To better characterize genetic susceptibility to childhood RMS, we evaluated the role of family history of cancer using data from the largest case-control study of RMS and the Utah Population Database (UPDB). RMS cases (n = 322) were obtained from the Children's Oncology Group (COG). Population-based controls (n = 322) were pair-matched to cases on race, sex, and age. Conditional logistic regression was used to evaluate the association between family history of cancer and childhood RMS. The results were validated using the UPDB, from which 130 RMS cases were identified and matched to controls (n = 1300) on sex and year of birth. The results were combined to generate summary odds ratios (OR(s) ) and 95% confidence intervals (CI). Having a first-degree relative with a cancer history was more common in RMS cases than controls (OR(s) = 1.39, 95% CI: 0.97-1.98). Notably, this association was stronger among those with embryonal RMS (OR(s) = 2.44, 95% CI: 1.54-3.86). Moreover, having a first-degree relative who was younger at diagnosis of cancer (<30 years) was associated with a greater risk of RMS (OR(s) = 2.37, 95% CI: 1.34-4.18). In the largest analysis of its kind, we found that most children diagnosed with RMS did not have a family history of cancer. However, our results indicate an increased risk of RMS (particularly embryonal RMS) in children who have a first-degree relative with cancer, and among those whose relatives were diagnosed with cancer at <30 years of age.

Url: http://www.ncbi.nlm.nih.gov/pubmed/25809884

Url: http://doi.wiley.com/10.1002/cam4.448

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Authors: Lupo, Philip J.; Danysh, Heather E.; Plon, Sharon E.; Curtin, Karen; Malkin, David; Hettmer, Simone; Hawkins, Douglas S.; Skapek, Stephen X.; Spector, Logan G.; Papworth, Karin; Melin, Beatrice; Erhardt, Erik B.; Grufferman, Seymour; Schiffman, Joshua D.

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Pages: 781-790

Volume: 4

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IPUMS NHGIS NAPP IHIS ATUS Terrapop