MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-Modified Association

Citation Type: Journal Article

Publication Year: 2021

ISSN: 0021-972X

DOI: 10.1210/CLINEM/DGAB337

Abstract: PURPOSE: To determine whether periodontal disease is positively associated with incident diabetes across the continuum of body mass levels (BMI) and test the hypothesis that the periodontal risk for incident diabetes is modified by BMI. METHODS: We included 5569 diabetes-free participants from Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities (ARIC) Study and followed them until 2018. Periodontal disease status was classified by periodontal profile class (PPC)-Stages and incident diabetes was based on participant report of physician diagnosis. We estimated the hazard ratios (HR) for diabetes using a competing risk model for each PPC-Stage. We assessed multiplicative interactions between periodontal disease and BMI (as a continuous variable) on risk of diabetes. RESULTS: During a median time of 19.4 years of follow-up, 1,348 incident diabetes cases and 1,529 deaths occurred. Compared to "healthy/incidental disease" Stage , participants with PPC-"severe periodontal disease" or "severe tooth loss" Stage and lower BMI had elevated risk for diabetes adjusting for demographic, smoking, education and biological variables when accounting for death as a competing risk with HRs 1.76 (95%CI 1.10-2.80) and 2.11 (95% CI 1.46-3.04), respectively. The interaction between PPC-stages and BMI was significant (p= 0.01). No significant associations of PPC-Stages with incident diabetes were present when BMI was above 31 kg/m 2. CONCLUSION: Periodontal disease was associated with incident diabetes, especially in non-obese participants. Dentists should be aware that periodontal disease is associated with incident diabetes but the association may be modified for patient's at higher BMI levels.

Url: https://academic.oup.com/jcem/article/106/9/e3546/6274982

User Submitted?: No

Authors: Zhang, Shaoping; Philips, Kamaira H; Moss, Kevin; Wu, Di; Adam, Hamdi S; Selvin, Elizabeth; Demmer, Ryan T.; Norby, Faye L; Mustapha, Indra Z; Beck, James D

Periodical (Full): The Journal of Clinical Endocrinology & Metabolism

Issue: 9

Volume: 106

Pages: e3546-e3558

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop