MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Hmong microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C): A phase II clinical study protocol

Citation Type: Journal Article

Publication Year: 2023

ISBN: 1111111111

ISSN: 1932-6203

DOI: 10.1371/JOURNAL.PONE.0279830

PMID: 36724193

Abstract: Background Hmong men in Minnesota exhibit a high prevalence of gout and hyperuricemia. Although evidence of vitamin C’s effectiveness as a treatment for gout is mixed, analysis of therapeutic benefit based on an individual’s multiomic signature may identify predictive markers of treatment success. Objectives The primary objective of the Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C) study was to assess the effectiveness of vitamin C on serum urate in Hmong adults with and without gout/hyperuricemia. The secondary objectives were to assess if 1) vitamin C impacts the taxonomic and functional patterns of microbiota; 2) taxonomic and functional patterns of microbiota impact vitamin C’s urate-lowering effects; 3) genetic variations impact vitamin C’s urate-lowering effects; 4) differential microbial biomarkers exist for patients with or without gout; and 5) there is an association between obesity, gut microbiota and gout/hyperuricemia. Methods This prospective open-labelled clinical trial was guided by community-based participatory research principles and conducted under research safety restrictions for SARS-CoV-2. We aimed to enroll a convenient sample of 180 Hmong adults (120 with gout/hyperuricemia and 60 without gout/hyperuricemia) who provided medical, demographic, dietary and anthropometric information. Participants took vitamin C 500mg twice daily for 8 weeks and provided pre-and post- samples of blood and urine for urate measurements as well as stool samples for gut microbiome. Salivary DNA was also collected for genetic markers relevant to uric acid disposition. Expected results We expected to quantify the impact of vitamin C on serum urate in Hmong adults with and without gout/hyperuricemia. The outcome will enhance our understanding of how gut microbiome and genomic variants impact the urate-lowering of vitamin C and associations between obesity, gut microbiota and gout/hyperuricemia. Ultimately, findings may improve our understanding of the causes and potential interventions that could be used to address health disparities in the prevalence and management of gout in this underserved population. Trial registration ClinicalTrials.gov NCT04938024 (first posted: 06/24/2021).

Url: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279830

User Submitted?: No

Authors: Wen, Ya Feng; Culhane-Pera, Kathleen A.; Pergament, Shannon L.; Moua, Yeng; Vue, Bai; Yang, Toua; Lo, Muaj; Sun, Boguang; Knights, Dan; Straka, Robert J.

Periodical (Full): PLOS ONE

Issue: 2

Volume: 18

Pages: e0279830

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop