MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Motoric cognitive risk syndrome: multicountry prevalence and dementia risk

Citation Type: Journal Article

Publication Year: 2014

ISSN: 1526-632X; 0028-3878

DOI: 10.1212/WNL.0000000000000717 [doi]

PMCID: PMC4150127

PMID: 25031288

Abstract: OBJECTIVES: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk. METHODS: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline >/=4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores >/=25 from 4 prospective cohort studies using Cox models adjusted for potential confounders. RESULTS: At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes. CONCLUSION: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.

User Submitted?: No

Authors: Verghese, J; Annweiler, C; Ayers, E; Barzilai, N; Beauchet, O; Bennett, David; Bridenbaugh, SA; Buchman, AS; Callisaya, ML; Camicioli, R; Capistrant, Benjamin D; Chatterjee, Soumyadeep; De Cock, AM; Ferrucci, L; Giladi, N; Guralnik, JM; Hausdorff, JM; Holtzer, R; Kim, KW; Kowal, P; Kressig, RW; Lim, JY; Lord, S; Meguro, K; Montero-Odasso, M; Muir-Hunter, SW; Noone, ML; Rochester, L; Srikanth, V; Wang, C

Periodical (Full): Neurology

Issue: 8

Volume: 83

Pages: 718-1443

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop