MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Leukocyte traits and exposure to ambient particulate matter air pollution in the women’s health initiative and atherosclerosis risk in communities study

Citation Type: Journal Article

Publication Year: 2020

ISSN: 15529924

DOI: 10.1289/EHP5360

PMID: 31903802

Abstract: BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations. OBJECTIVES: Our objective was to estimate PM–leukocyte associations among U.S. women and men in the Women’s Health Initiative and Atherosclerosis Risk in Communities study (n = 165,675). METHODS: We based the PM–leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of PM ≤ 10, ≤2:5, and 2:5–10 lm in diameter (PM10, PM2:5, and PM2:5–10, respectively) were available. We multiply imputed missing data using chained equations and estimated PM–leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (n = 8,457), we also estimated PM–leukocyte proportion associations in compositional data analyses. RESULTS: We found a 12 cells=lL (95% confidence interval: −9, 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a −1:1% (−1:9%, −0:3%) lower CD8+ T-cell proportion per 10-lg=m3 increase in 1-month mean PM2:5. However, shorter-duration PM10 exposures were inversely and only modestly associated with leukocyte count. DISCUSSION: The PM2:5 –leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. https://doi.org/10.1289/EHP5360.

Url: https://pubmed.ncbi.nlm.nih.gov/31903802/

User Submitted?: No

Authors: Gondalia, Rahul; Holliday, Katelyn M.; Baldassari, Antoine; Justice, Anne E.; Stewart, James D.; Liao, Duanping; Yanosky, Jeff D.; Engel, Stephanie M.; Jordahl, Kristina M.; Bhatti, Parveen; Horvath, Steve; Assimes, Themistocles L.; Pankow, James S; Demerath, Ellen W.; Guan, Weihua; Fornage, Myriam; Bressler, Jan; North, Kari E.; Conneely, Karen N.; Li, Yun; Hou, Lifang; Baccarelli, Andrea A.; Whitsel, Eric A.

Periodical (Full): Environmental Health Perspectives

Issue: 1

Volume: 128

Pages:

Countries:

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