MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Causality and pathway search in microarray time series experiment

Citation Type: Journal Article

Publication Year: 2007

ISSN: 13674803

DOI: 10.1093/bioinformatics/btl598

PMID: 17158516

Abstract: Motivation: Interaction among time series can be explored in many ways. All the approach has the usual problem of low power and high dimensional model. Here we attempted to build a causality network among a set of time series. The causality has been established by Granger causality, and then constructing the pathway has been implemented by finding the Minimal Spanning Tree within each connected component of the inferred network. False discovery rate measurement has been used to identify the most significant causalities. Results: Simulation shows good convergence and accuracy of the algorithm. Robustness of the procedure has been demonstrated by applying the algorithm in a non-stationary time series setup. Application of the algorithm in a real dataset identified many causalities, with some overlap with previously known ones. Assembled network of the genes reveals features of the network that are common wisdom about naturally occurring networks. © 2007 Oxford University Press.

Url: https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btl598

User Submitted?: No

Authors: Mukhopadhyay, Nitai D.; Chatterjee, Snigdhansu

Periodical (Full): Bioinformatics

Issue: 4

Volume: 23

Pages: 442-449

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop