MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Cancer in women after assisted reproductive technology

Citation Type: Book, Whole

Publication Year: 2015

ISSN: 00150282

DOI: 10.1016/j.fertnstert.2015.07.1135

PMID: 26271227

Abstract: OBJECTIVE\nTo evaluate the risk of cancer after assisted reproductive technology (ART) therapy. \n\nDESIGN\nLongitudinal cohort study. \n\nSETTING\nNot applicable. \n\nPATIENT(S)\nNew York, Texas, and Illinois residents between 2004 and 2009, treated with ART, comprising cycles of 113,226 women, including 53,859 women without prior ART treatment, who were linked to their respective state cancer registries and whose cycles were reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS). \n\nINTERVENTION(S)\nNone. \n\nMAIN OUTCOME MEASURE(S)\nDiagnosis of cancer, as reported to the state cancer registry; standardized incidence ratios (SIR) and their 95% confidence intervals, comparing the observed to expected cancer cases based on age-specific cancer rates in the general population of each state. \n\nRESULT(S)\nAmong the cohort of women without prior ART therapy, hazard ratios (HR) and 95% confidence intervals (CI) were calculated for treatment parameters and reproductive history factors. The mean follow-up period was 4.87 years; among women without prior ART, 450 women developed 460 cancers. Women treated with ART had a statistically significantly lower risk for all cancers (for all women: SIR 0.78; CI, 0.73–0.83; women without prior ART: SIR 0.75; CI, 0.68–0.82), breast cancer, and all female genital cancers; a non-statistically-significant lower risk for endocrine and uterine cancer; and a non-statistically-significant higher risk for melanoma and ovarian cancer. Among women without prior ART, we found no statistically significant increased HR by parity, number of cycles, cumulative follicle-stimulating hormone dosage, or cycle outcome. \n\nCONCLUSION(S)\nWomen initiating ART treatment have no greater risk for developing cancer after nearly 5 years of follow-up compared with the general population and with other women treated with ART.

Url: http://linkinghub.elsevier.com/retrieve/pii/S0015028215016465

User Submitted?: No

Authors: Luke, Barbara; Brown, Morton B.; Spector, Logan G.; Missmer, Stacey A.; Leach, Richard E.; Williams, Melanie; Koch, Lori; Smith, Yolanda R.; Stern, Judy E.; Ball, G. David; Schymura, Maria J.

Publisher:

Publisher Location:

Pages: 1218-1226

Volume: 104

Edition:

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop