Full Citation

Title: Childhood cancer following neonatal oxygen supplementation

Citation Type: Book, Whole

Publication Year: 2005

ISBN:

ISSN: 00223476

DOI: 10.1016/j.jpeds.2005.03.008

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Abstract: Objective: To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP). Study design: The CPP consisted of 54,795 children born between 1959 and 1966 and followed to age 8 years. We used Cox proportional hazards modeling to examine the association between history of neonatal O2and cancer (n = 48). Results: The hazard ratio (HR) for any O2was 1.77 (95% confidence interval [CI] = 0.94 to 3.35). The HR for continuous duration of O2was near 1 and not significant. However, the HRs were 0.69 (95% CI = 0.17 to 2.88) and 2.87 (95% CI = 1.46 to 5.66) when comparing 0 to 2 and 3 or more minutes of O2, respectively, to no O2. The latter association was weaker (HR = 2.00; 95% CI = 0.88 to 4.54) and not significant (P = .10) when analysis was restricted to cancers diagnosed after age 1 year (n = 41). Conclusions: These findings are consistent with an association between O2for 3 minutes or longer and cancer in childhood, and should serve as a basis for further study. Copyright © 2005 Elsevier Inc. All rights reserved.

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Authors: Spector, Logan G.; Klebanoff, Mark A.; Feusner, James H.; Georgieff, Michael; Ross, Julie A.

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Pages: 27-31

Volume: 147

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