MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Genetic ancestry, differential gene expression, and survival in pediatric B-cell acute lymphoblastic leukemia

Citation Type: Journal Article

Publication Year: 2022

ISSN: 2045-7634

DOI: 10.1002/CAM4.5266

PMID: 36127808

Abstract: Background: Black children have lower incidence yet worse survival than White and Latinx children with B-cell acute lymphoblastic leukemia (B-ALL). It is unclear how reported race/ethnicity (RRE) is associated with death in B-ALL after accounting for differentially expressed genes associated with genetic ancestry. Methods: Using Phase 1 and 2 NCI TARGET B-ALL cases (N = 273; RRE-Black = 21, RRE-White = 162, RRE-Latinx = 69, RRE-Other = 9, RRE-Unknown = 12), we estimated proportions of African (AFR), European (EUR), and Amerindian (AMR) genetic ancestry. We estimated hazard ratios (HR) and 95% confidence intervals (95% CI) between ancestry and death while adjusting for RRE and clinical measures. We identified genes associated with genetic ancestry and adjusted for them in RRE and death associations. Results: Genetic ancestry varied within RRE (RRE-Black, AFR proportion: Mean: 78.5%, Range: 38.2%–93.6%; RRE-White, EUR proportion: Mean: 94%, Range: 1.6%–99.9%; RRE-Latinx, AMR proportion: Mean: 52.0%, Range: 1.2%–98.7%). We identified 10, 1, and 6 differentially expressed genes (padjusted <0.05) associated with AFR, AMR, and EUR ancestry proportion, respectively. We found AMR and AFR ancestry were statistically significantly associated with death (AMR each 10% HR: 1.05, 95% CI: 1.03–1.17, AFR each 10% increase HR: 1.03, 95% CI:1.01–1.19). RRE differences in the risk of death were larger in magnitude upon adjustment for genes associated with genetic ancestry for RRE-Black, but not RRE-Latinx children (RRE-Black HR: 3.35, 95% CI: 1.31, 8.53; RRE-Latinx HR: 1.47, 0.88–2.45). Conclusions: Our work highlights B-ALL survival differences by RRE after adjusting for ancestry differentially expressed genes suggesting other factors impacting survival are important.

Url: https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.5266

Url: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.5266

Url: https://onlinelibrary.wiley.com/doi/10.1002/cam4.5266

User Submitted?: No

Authors: Barragan, Freddy A.; Mills, Lauren J.; Raduski, Andrew R.; Marcotte, Erin L.; Grinde, Kelsey E.; Spector, Logan G.; Williams, Lindsay A.

Periodical (Full): Cancer Medicine

Issue:

Volume: 00

Pages: 1-12

Countries:

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