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Title: Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
Citation Type: Book, Whole
Publication Year: 2010
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DOI: 10.1038/ng.626
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Abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
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Authors: Conde, Lucia; Halperin, Eran; Akers, Nicholas; Brown, Kevin; Smedby, Karin; Rothman, Nathaniel; Nieters, Alexandra; Slager, Susan L.; Brooks-Wilson, Angela; Agana, Luz; Riby, Jacques; Liu, Jianjun; Adami, Hans-Olov; Darabi, Hatef; Hjalgrim, Henrik; Low, Hui-Qi; Humphreys, Keith; Melbye, Mads; Chang, Ellen; Skibola, Christine
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Pages: 661-664
Volume: 42
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