MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: In Utero Origins of Acute Leukemia in Children

Citation Type: Journal Article

Publication Year: 2024

ISSN: 2227-9059

DOI: 10.3390/BIOMEDICINES12010236

Abstract: Acute leukemias, mainly consisting of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), comprise a major diagnostic group among hematologic cancers. Due to the early age at onset of ALL, particularly, it has long been suspected that acute leukemias of childhood may have an in utero origin. This supposition has motivated many investigations seeking direct proof of prenatal leukemogenesis, in particular, twin and “backtracking studies”. The suspected in utero origin has also focused on gestation as a critical window of risk, resulting in a rich literature on prenatal risk factors for pediatric acute leukemias. In this narrative review, we recount the circumstantial and direct evidence for an in utero origin of childhood acute leukemias.

Url: https://www.mdpi.com/2227-9059/12/1/236/htm

Url: https://www.mdpi.com/2227-9059/12/1/236

User Submitted?: No

Authors: Smith, Adam J. de; Spector, Logan G.

Periodical (Full): Biomedicines 2024, Vol. 12, Page 236

Issue: 1

Volume: 12

Pages: 236

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop