MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families

Citation Type: Book, Whole

Publication Year: 2010

ISBN: 1365-2141 (Electronic)\r0007-1048 (Linking)

ISSN: 00071048

DOI: 10.1111/j.1365-2141.2010.08339.x

PMID: 20738309

Abstract: Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic haematological condition characterized by low absolute levels of B-cell clones with a surface immunophenotype similar to that of chronic lymphocytic leukaemia (CLL). In the general population, MBL increases with age with a prevalence of 5-9% in individuals over age 60 years. It has been reported to be higher among first-degree relatives from CLL families. We report results of multi-parameter flow cytometry among 505 first-degree relatives with no personal history of lymphoproliferative disease from 140 families having at least two cases of CLL. Seventeen percent of relatives had MBL. Age was the most important determinant where the probability for developing MBL by age 90 years was 61%. MBL clustered in certain families but clustering was independent of the number of known CLL cases in a family. As is the case with CLL, males had a significantly higher risk for MBL than did females (P = 0·04). MBL patients had significantly higher mean absolute lymphocyte counts (2·4 × 10(9) /l) and B-cell counts (0·53 × 10(9) /l) than those with a normal B-cell immuno-phenotype. Our findings show that MBL occurs at a very high rate in high risk CLL families. Both the age and gender distribution of MBL are parallel to CLL, implying a shared inherited risk.

User Submitted?: No

Authors: Goldin, Lynn R.; Lanasa, Mark C.; Slager, Susan L.; Cerhan, James R; Vachon, Celine M.; Strom, Sara S.; Camp, Nicola J.; Spector, Logan G.; Leis, Jose F.; Morrison, Vicki A.; Glenn, Martha; Rabe, Kari G.; Achenbach, Sara J.; Algood, Sallie D.; Abbasi, Fatima; Fontaine, Laura; Yau, Michelle; Rassenti, Laura Z.; Kay, Neil E.; Call, Timothy G.; Hanson, Curtis A.; Weinberg, J. Brice; Marti, Gerald E.; Caporaso, Neil E.

Publisher:

Publisher Location:

Pages: 152-158

Volume: 151

Edition:

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop