MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Comparability and representativeness of control groups in a case-control study of infant leukemia: a report from the Children's Oncology Group.

Citation Type: Book, Whole

Publication Year: 2009

ISSN: 1476-6256

DOI: 10.1093/aje/kwp127

PMID: 19498073

Abstract: Traditionally, controls in US pediatric cancer studies were selected through random digit dialing. With declining participation and lack of nonparticipant information, random digit dialing (RDD) controls may be substandard. Birth certificate (BC) controls are an alternative, because they are population based and include data from nonparticipants. The authors examined controls collected by random digit dialing and birth certificates for a Children's Oncology Group case-control study of infant leukemia in 1995-2006. Demographic variables were used to assess differences in RDD and BC controls and their representativeness. RDD and BC controls did not differ significantly with regard to maternal variables (age, race, education, marital status, alcohol during pregnancy) or child variables (sex, gestational age, birth weight), but they varied in smoking during pregnancy (22% RDD controls, 12% BC controls) (P = 0.05). The study's combined control group differed significantly from US births: Mothers of controls were more likely to be older (29.8 vs. 27.2 years), white (84% vs. 59%), and married (85% vs. 67%) and to have >16 years of education (37% vs. 25%). Control children were more often full term (88% vs. 81%) and heavier (3,436 vs. 3,317 g). Finally, participating BC mothers were likely to be older and to have more education than nonparticipants. Thus, the study's control groups were comparable but differed from the population of interest.

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2727172&tool=pmcentrez&rendertype=abstract

User Submitted?: No

Authors: Puumala, Susan E.; Spector, Logan G.; Robison, Leslie L.; Bunin, Greta R.; Olshan, Andrew F.; Linabery, Amy M.; Roesler, Michelle; Blair, Cindy K.; Ross, Julie A.

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Pages: 379-87

Volume: 170

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